Set out three shallow bowls. In the first bowl, mix the flour with the salt and black pepper. In the second bowl, whisk the eggs. In the third bowl, combine the Panko breadcrumbs with the garlic powder, onion powder, and smoked paprika.
Take one chicken tender at a time and dredge it in the flour, shaking off any excess. Dip it into the egg wash until fully coated, and finally, press it firmly into the Panko mixture until it is completely covered with crumbs.
Lightly spray the air fryer basket with olive oil. Place the breaded chicken tenders in the basket in a single layer, ensuring they do not overlap. Spray the tops of the chicken tenders generously with olive oil spray to help them brown.
Cook the chicken at 400°F (200°C) for 6 minutes. Open the basket, flip the tenders over, and spray the other side lightly with oil. Cook for another 5 to 6 minutes, or until the chicken reaches an internal temperature of 165°F and the outside is golden and crispy.